Medical Dictionary

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P-450-cam, Cytochrome

A monooxygenase heme-thiolate (cytochrome P-450) with camphor bound at the active site. It acts as the terminal monooxygenase in the d-camphor monooxygenase system. Under anaerobic conditions, this enzyme reduces the polyhalogenated compounds bound at the camphor-binding site. Additionally, it is the only cytochrome P-450 enzyme with a known crystal structure. (Proc Natl Acad Sci U S A 1989; 86(20):7823-7; Proteins 1991;11(3):184-204) EC 1.14.15.1.

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