Medical Dictionary

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C1 q

Subcomponent of complement 1 (C1) which recognizes and binds to the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M initiating the classical complement pathway. The interaction of C1q and immunoglobulin activates C1r and C1s. The activated C1r and C1s molecules are cleaved off the complex by C1-inhibitor, allowing the collagen-like region of C1q to become accessible for interaction with cell membrane C1q receptors.

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