Experts in Medical & Radiologic Imaging
RADIOLOGY
SECOND OPINION
Medical Conditions
Bacterial Topoisomerase I
Bacterial enzymes of the DNA TOPOISOMERASES TYPE I class that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
